Detection of leptomeningeal disease using cell-free DNA from cerebrospinal fluid
MD White, RH Klein, B Shaw, A Kim… - JAMA Network …, 2021 - jamanetwork.com
Importance Leptomeningeal disease (LMD) is a devastating complication of cancer that is
frequently underdiagnosed owing to the low sensitivity of cerebrospinal fluid (CSF) cytologic
assessment, the current benchmark diagnostic method. Improving diagnostic sensitivity may
lead to improved treatment decisions. Objective To assess whether cell-free DNA (cfDNA)
analysis of CSF may be used to diagnose LMD more accurately than cytologic analysis.
Design, Setting, and Participants This diagnostic study conducted in a neuro-oncology clinic …
frequently underdiagnosed owing to the low sensitivity of cerebrospinal fluid (CSF) cytologic
assessment, the current benchmark diagnostic method. Improving diagnostic sensitivity may
lead to improved treatment decisions. Objective To assess whether cell-free DNA (cfDNA)
analysis of CSF may be used to diagnose LMD more accurately than cytologic analysis.
Design, Setting, and Participants This diagnostic study conducted in a neuro-oncology clinic …
